KMID : 0385920090200040453
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Journal of the Korean Society of Emergency Medicine 2009 Volume.20 No. 4 p.453 ~ p.457
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A Case of Hemodynamically Unstable Bradycardia after Risperidone Overdose
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Kwon Beom-June
Kim Dong-Bin Yang Jin-Hong Jang Sung-Won Cho Eun-Ju Seung Ki-Bae Rho Tai-Ho Kim Jae-Hyung Choi Kyu-Bo
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Abstract
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Risperidone is an atypical antipsychotic medication commonly used to treat psychotic illness, such as schizophrenia. It has strong serotonin and dopamine receptor antagonism and antagonist activity at alpha-adrenergic receptors and histamine receptors. An overdose of risperidone can cause tachycardia, hypertension, hypotension, prolonged QT interval, and bradycardia. Risperidone overdose is rare, but life-threatening. Here, we present the rare case of a 33-year-old woman who ingested risperidone overdose for the purposes of suicide, developing hemodynamically unstable bradycardia with trifascicular block, leading to fatality. Lessons from our case report are of urgent consideration for temporary pacemaker insertion, and use of alpha-1 agonist, such as phenylephrine in cases of hemodynamically unstable bradycardia by risperidone overdose. Prompt and appropriate identification and interventions are essential for the successful management of risperidone overdose.
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KEYWORD
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Risperidone, Bradycardia, Trifascicular block
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